elevated thyroid peroxidase antibody after thyroidectomy

BACKGROUND Compared to Adequate Thyroid Hormone Replacement 2019 Annals of Internal Medicine. Disclaimer. Third, the degree of hyperthyroidism and the severity of symptoms should be considered. https://familydoctor.org/familydoctor/en/diseases-conditions/thyroiditis.html. Method In a retrospective study, we included patients with DTC who had raised TgAb following total thyroidectomy . I had a stroke about nine months ago and had an ultrasound to check the choriodid arteries, they found that my thyroid was enlarged and irregular texture. This week, researchers have added another to the listthe thyroid. Survival and regression analysis was used to determine TgAb resolution time course. If you are a Mayo Clinic patient, this could Consider a 1996 study by Aarflot and Bruusgaard. TPO plays an important role in the production of thyroid hormones. Indeed, some patients with high TPOAb levels and normal thyroid hormone levels (without medication) will present with symptoms similar to those of patients with hypothyroidism. Given the known challenge of thyroidectomy in patients with HT, surgery has typically been reserved for cases of con-comitant malignancy or substernal goiter with compressive Heat intolerance. Certainly this study needs to be repeated and longer term studies in this area will certainly be of benefit. The thyroid hormone replacement only group had no significant change in either the health survey or the fatigue scores. Subacute thyroiditis is a transient thyrotoxic state characterized by anterior neck pain, suppressed TSH, and low uptake of iodine 123 on thyroid scanning. Hyperthyroidism, or overactive thyroid, happens when your thyroid gland makes more thyroid hormones than your body needs. Not per se: Antibodies to thyroglobulin are not an issue if you had a thyroidectomy. 2018 Nov;33(6):1050-1057. doi: 10.3904/kjim.2018.289. In this narrative review, the major results and limitations of the . Even though the results of this study indicate that surgical management of Hashimotos thyroiditis may be beneficial, it is not clear whether undergoing surgery for this relatively common disease is necessary to treat symptoms in all patients. Tg was still undetectable. Measurement of free T3 is possible, but is often not reliable and therefore not typically helpful. TgAb are common in patients with thyroid cancer but resolve after treatment at approximately -11% IU/mL per month from preoperative levels with median resolution at 11.0 mo. A publication of the American Thyroid Association, Summaries for the Public from recent articles in Clinical Thyroidology, Table of Contents | PDF File for Saving and Printing, HYPOTHYROIDISM This antibody causes the thyroid to be overactive in Graves Disease. The thyroid gland is a butterfly-shaped endocrine gland that is normally located in the lower front of the neck. It makes hormones that control the way the body uses energy. This frequently happens during pregnancy and with the use of birth control pills. Patients with subacute thyroiditis should be started on high-dose acetylsalicylic acid or nonsteroidal anti-inflammatory drugs as first-line therapy. This content does not have an Arabic version. In autoimmune disorders, your immune system makes antibodies that mistakenly attack normal tissue. Image: Sebastian Kaulitzki/Science Photo Library/Getty Images. Clinical aggressiveness and long-term outcome in patients with papillary thyroid cancer and circulating anti-thyroglobulin autoantibodies. The follow-up of patients with differentiated thyroid cancer and undetectable thyroglobulin (Tg) and Tg antibodies during ablation. Antibodies can be high, even though you have no symptoms and/or thyroid test levels are in the normal range. Patients may also have typical symptoms of hyperthyroidism.20,21 Many cases of subacute thyroiditis follow an upper respiratory viral illness, which is thought to trigger an inflammatory destruction of thyroid follicles. Accessed Aug. 5, 2020. We offer this Site AS IS and without any warranties. The major thyroid hormone secreted by the thyroid gland is thyroxine, also called T4 because it contains four iodine atoms. Chronic fatigue, chronic irritability, dry hair, chronic nervousness and a history of breast cancer can all be linked to elevated TPO thyroid antibodies levels. However, in some patients, symptoms may persist despite what appears to be adequate treatment based on blood tests of thyroid function. Accessed Aug. 5, 2020. Table 1 summarizes key aspects of thyroiditis, including less common forms. However, monitoring anti-TPO antibodies come with their own limitations. This site needs JavaScript to work properly. This would indicate that the antibodies have not yet destroyed enough of your thyroid, to keep . Approximately 50% of women who are TPOAb positive early in pregnancy go on to develop some form of post-partum thyroid dysfunction, usually of a transient nature. Thyroid cancer can also produce elevated thyroglobulin antibodies. This antibody causes the thyroid to be overactive in. sured by elevated thyroid peroxidase antibody (TPO Ab).6,7 To date, there is no algorithm for treatment in these refractory cases. But the presence of TPO antibodies may increase the risk of future thyroid disorders. The Best IOL for 2022 RXSight Light Adjusted Lens, Will refractive surgery such as LASIK keep me out of glasses all my life. MEDICATIONS THAT INTERFERE WITH THYROID FUNCTION TESTING. Treatment with levothyroxine is generally initiated at 50 mcg per day and titrated to achieve a TSH level between 1 and 2.5 mIU per L. Given the natural course of postpartum thyroiditis, tapering of levothyroxine may be considered after 12 months of therapy.17 This may be accomplished by reducing the dose by 50% and repeating thyroid function testing at four- to eight-week intervals.17 Alternatively, it is reasonable to continue levothyroxine therapy during a woman's reproductive years, given the potential adverse effects of maternal hypothyroidism and the high likelihood of recurrence of postpartum thyroiditis, which approaches 70% with subsequent pregnancies.17 Hypothyroidism that occurs beyond one year postpartum should not be classified as postpartum thyroiditis. Treatment with levothyroxine may result in iatrogenic hyperthyroidism. REVERSE T3 What are the actual levels, with reference ranges, for the Free T3 and Free T4? T4 is the main form of thyroid hormone circulating in the blood. Persistently elevated levels after thyroidectomy were not associated with disease recurrence in our series. Fam Med. It can, however, present without a goiter (atrophic form). Replacement therapy means the goal is a TSH in the normal range and is the usual therapy. KL2 TR000428/TR/NCATS NIH HHS/United States, R01 CA176911/CA/NCI NIH HHS/United States, T35 DK062709/DK/NIDDK NIH HHS/United States, UL1 TR000427/TR/NCATS NIH HHS/United States. The most common is Hashimoto thyroiditis; patients typically present with a nontender goiter, hypothyroidism, and an elevated thyroid peroxidase antibody level. 2. 8. Log-Rank analysis showed that patients resolved at a median 11 months. The Endocrine Society/American Association of Clinical Endocrinologists. I had TT in January 2009, and in November 2016 my Tg level was suddenly detectable after being undetectable for years. Table 2 summarizes drugs associated with thyroiditis.18, Figure 1 is an algorithm for the diagnosis of thyroiditis.9, Presence of nontender goiter; thyroid function tests; elevated TPO antibody levels, Presence of an elevated TPO antibody level confers risk for many types of thyroid dysfunction and is a general marker of thyroid autoimmunity; a frankly elevated TPO antibody level is more specific for Hashimoto thyroiditis, In type 1 amiodarone-induced thyrotoxicosis there is increased synthesis of thyroid hormone (usually in patients with preexisting goiter), In type 2 amiodarone-induced thyrotoxicosis there is excess release of thyroxine and triiodothyronine into the circulation caused by destructive thyroiditis, Type 1 is treated with antithyroid medications (thioureas) and type 2 is treated with glucocorticoids; in both cases, beta blockers can be used for symptoms of hyperthyroidism1,2. https://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/thyroid-disorders/overview-of-thyroid-function?query=overview thyroid function. The free T4 or T3 is the hormone that is unbound and able to enter and affect the body tissues. A Total T4 measures the bound and free hormone and can change when binding proteins differ (see above). high when your TSH level is below normal, but that is acceptable as long . Anterior neck pain in the area of the thyroid bed is the cardinal feature of subacute thyroiditis and is most often what prompts patients to seek medical attention. Some people with TPO antibodies may not have thyroid disease. 4 Iatrogenic forms of hypothyroidism occur after thyroid surgery, radioiodine therapy, and neck . It is used most often in patients who have had surgery for thyroid cancer in order to monitor them after treatment. FOIA A 2019 study found that anti-TG antibodies are elevated in 60-80% of patients with . Eskes SA, Endert E, Fliers E, Birnie E, Hollenbach B, Schomburg L, et al. 2014;61(10):961-5. doi: 10.1507/endocrj.ej14-0275. a TSH level between 5 and 10 mlU/litre on 2 separate occasions 3 months apart, and. Anti thyroid peroxidase antibody - <28 U/ml (range <60) Rubella . A TPO test detects antibodies against TPO in the blood. Advertising and sponsorship opportunities. There is no role for antibiotics in the treatment of subacute thyroiditis, and referral for thyroidectomy is not warranted.25 The differential diagnosis for thyroid bed pain includes hemorrhage into a thyroid cyst and acute infectious or suppurative thyroiditis. These antibodies can be a sign of: Hashimoto disease, also known as Hashimoto thyroiditis. Background: Cautions: The test is most sensitive for detection of thyroid cancer recurrence when patients are off thyroid replacement long enough to have an elevated thyroid-stimulating hormone (TSH) prior to drawing the specimen. Phan HT, Jager PL, van der Wal JE, Sluiter WJ, Plukker JT, Dierckx RA, Wolffenbuttel BH, Links TP. A 41-year-old female asked: information highlighted below and resubmit the form. As in other forms of destructive thyroiditis, preformed thyroid hormone is released into the blood, leading to increased levels of thyroid hormone and suppressed TSH. Most of these patients will have recovery of euthyroidism, but some may benefit from treatment aimed at relieving symptoms of hyperthyroidism or hypothyroidism, provided they are monitored for anticipated changes in thyroid function. Changing Trend of Thyroglobulin Antibodies in Patients With Differentiated Thyroid Cancer Treated With Total Thyroidectomy Without. Log-Rank analysis could not determine a relationship between TgAb status and recurrent cancer. Conclusions: Log-Rank analysis showed. Takasu N, Matsushita M. Changes of TSH-stimulation block - ing antibody (TSBAb) and thyroid stimulating antibody (TSAb) over 10 years in 34 TSBAb-positive patients with hy - pothyroidism and in 98 TSAb-positive Graves' patients with WHAT ARE THE IMPLICATIONS OF THIS STUDY? First, the laboratory test result should be confirmed, and free thyroxine (T4) and free triiodothyronine (T3) levels should be measured. [ 1] Bethesda, MD 20894, Web Policies Patients should be monitored for changes in thyroid function. Copyright 2014 by the American Academy of Family Physicians. T4 TESTS In most healthy individuals, a normal TSH value means that the thyroid is functioning properly. Release of preformed thyroid hormone into the bloodstream may result in hyperthyroidism. The outcome of the study was a patient-reported health score on the generic Short Form-36 Health Survey (SF-36) after 18 months. You may not need that much TSH-suppression, but most people, even Stage 1, after thyroid cancer keep their TSH *under* 1.0 for the first 5 years after TT. That was the case for me. Unexplained weight loss. This may be followed by transient or permanent hypothyroidism as a result of depletion of thyroid hormone stores and destruction of thyroid hormoneproducing cells. The https:// ensures that you are connecting to the information and will only use or disclose that information as set forth in our notice of Graves' disease is an autoimmune disease of the thyroid . Reverse T3 is a biologically inactive protein that is structurally very similar to T3, but the iodine atoms are placed in different locations, which makes it inactive. The important thing is not what your results look like on paper, but how you feel with them at the current levels; if you don't feel well, there's something going on - either you thyroid levels are not optimal for you, or there's something else. Methods: Data of 2,352 patients who committed thyroidectomy from January 2018 to December 2018 at our institution were retrospectively reviewed.Of which, 806 patients diagnosed with thyroid . If thyroglobulin levels are low even in the presence of stimulation by a raised TSH, this is very reassuring and indicates absence of recurrence in papillary and follicular thyroid cancers (differentiated thyroid cancers). Thyroid stimulating immunoglobulin or TSI for short (1) is the name of a blood test that is used to identify the presence of autoimmune disease in those with hyperthyroidism. A very high RAIU is seen in individuals whose thyroid gland is overactive (hyperthyroidism), while a low RAIU is seen when the thyroid gland is underactive (hypothyroidism). Our purpose was to describe the TgAb resolution time course and the significance of persistent antibody elevation after thyroidectomy. The thyroid examination will commonly reveal a firm, bumpy gland with symmetric enlargement. 3. 6 months later the LN was still elevated but the Tg was detectable at 0.7. Learn how we can help. STIs are the most common cause of genital sores. A list of national and international resources and hotlines to help connect you to needed health and medical services. Mayo Clinic does not endorse companies or products. Often, even when these are "in range", the patient does not feel well. Herpes spreads by oral, vaginal and anal sex. Antithyroid peroxidase antibodies in patients with high normal range thyroid stimulating hormone. Xu J, Bergren R, Schneider D, Chen H, Sippel RS. For example, positive anti-thyroid peroxidase and/or anti-thyroglobulin antibodies in a patient with hypothyroidism result in a diagnosis of Hashimoto's thyroiditis. Careers. In its mildest form, hyperthyroidism may not cause noticeable symptoms; however, in some patients, excess thyroid hormone and the resulting effects on the body can have significant consequences. American Thyroid Association. Thyroid Antibodies like a title) Thyroid Peroxidase AB 24 H Thyroglobulin AB <1 Changes in serum thyroglobulin antibody levels as a dynamic prognostic factor for early-phase recurrence of thyroglobulin antibody-positive papillary thyroid carcinoma after total thyroidectomy. J Surg Res. TPO converts iodide ions absorbed from food into an active form of iodine to be used by the body. TPO plays an important role in the production of thyroid hormones. The thyroids job is to make thyroid hormones, which are secreted into the blood and then carried to every tissue in the body. 1.50 - 38.5 ng/mL for women. Some studies suggest that TPOAb may cross-react with tissues other than the thyroid and may contribute to inflammation and general symptoms. Several case reports and case series have also shown that COVID-19 can cause subacute thyroiditis. If the patient presents beyond the thyrotoxic phase, which typically lasts four to eight weeks, TSH and free T4 levels may be low. While TPO-antibodies are more indicative of Hashimotos thyroiditis, elevated anti-TG antibodies are often reported on lab results, creating concern for patients. The normal range for thyroglobulin is: 1.40 - 29.2 ng/mL (g/L) for men. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Introduction: Papillary thyroid cancer (PTC) is the most common endocrine malignancy. Postpartum thyroiditis is transient or persistent thyroid dysfunction that occurs within one year of childbirth, miscarriage, or medical abortion. Antibodies that attack the thyroid gland cause swelling, rarely tenderness and reduced function of the thyroid. This is a paradox of sorts, but they do settle down. Thyroid hormone supplementation is generally not necessary for the transient hypothyroid phase of subacute thyroiditis unless patients are symptomatic or have clear signs of hypothyroidism. This study enrolled patients with hypothyroidism due to Hashimotos thyroiditis who received treatment with thyroidectomy and thyroid hormone replacement or thyroid hormone replacement alone. Because my daughter has Primary Biliary Cirrohisis our doctor ran an AMA and ANA which have all come back negitive. . All patients were stratified to TgAb+/- groups and then further divided into those with recurrent cancer and those without. High thyroid antibodies can also cause an imbalance in hormone production which can . By measuring the amount of radioactivity that is taken up by the thyroid gland (radioactive iodine uptake, RAIU), doctors may determine whether the gland is functioning normally. Patients with overt hyperthyroidism (suppressed TSH and elevated free thyroid hormone levels) and significant symptoms can be treated with beta blockers, regardless of the etiology. Patients with severe thyroid pain and systemic symptoms (e.g., high fever, leukocytosis, cervical lymphadenopathy) should undergo fine-needle aspiration to rule out infectious thyroiditis. Subacute thyroiditis is self-limited, and in most cases the thyroid gland spontaneously resumes normal thyroid hormone production after several months. Women with postpartum thyroiditis and subclinical hypothyroidism should be treated with levothyroxine to achieve a TSH level of less than 2.5 mIU per L if they are pregnant or desire fertility.15. A high TSH level indicates that the thyroid gland is not making enough thyroid hormone (primary hypothyroidism). Thyroglobulin Antibodies (TgAb) Although thyroglobulin antibodies interfere with the measure of Thyroid surgery for patients with Hashimotos disease. If persistent symptoms in patients with Hashimotos thyroiditis are caused by the active autoimmune process rather than by thyroid hormone status, removing the thyroid gland through surgery may reduce the levels of the TPOAb and improve some symptoms. Median time to TgAb resolution was 11.0 2.3 mo, and the majority resolved by 32.4 mo. Hashimoto's thyroiditis is an autoimmune disorder where antibodies attack and destroy the thyroid. Hypothyroidism: a condition where the thyroid gland is underactive and doesnt produce enough thyroid hormone. Thus, the thyroid and the pituitary, like a heater and thermostat, turn on and off. Reading and interpreting thyroid blood tests results can often be a challenge. 174 views Reviewed >2 years ago. Chronic autoimmune thyroiditis (Hashimoto thyroiditis, chronic lymphocytic thyroiditis), Hypothyroidism; rarely thyrotoxicosis secondary to alternating stimulating and inhibiting thyroid autoantibodies, Infectious thyroiditis (suppurative thyroiditis), Thyroid pain, high fever, leukocytosis, and cervical lymphadenopathy; focal inflammation may result in compressive symptoms such as dysphonia or dysphagia; patients may assume a posture to limit neck extension; palpation may reveal focal or diffuse swelling of the thyroid gland and the overlying skin will be warm and erythematous; presence of fluctuance suggests abscess formation, Multiple infectious organisms, most commonly bacterial, Thyroid fine-needle aspiration with Gram stain and culture; blood cultures; neck magnetic resonance imaging or computed tomography with contrast media; plain radiography of the lateral neck may reveal gas in the soft tissues; thyroid autoantibodies are generally absent; serum thyroxine and triiodothyronine levels are usually normal, Acute complications may include septicemia and acute airway obstruction; later sequelae of the acute infection may include transient hypothyroidism or vocal cord paralysis, Hospitalization and treatment with intravenous antibiotics (nafcillin plus gentamicin or a third-generation cephalosporin); abscess formation may necessitate surgical drainage; euthyroidism is generally restored after treatment of infection, Hyperthyroidism alone; hyperthyroidism followed by hypothyroidism; or hypothyroidism alone within one year of parturition, Thyroid function tests; elevated TPO antibody levels; low radioactive iodine uptake in the hyperthyroid phase, Euthyroidism is generally achieved by 18 months, but up to 25% of women become permanently hypothyroid; high rate of recurrence with subsequent pregnancies, Beta blockers can be considered for significant hyperthyroid symptoms (in the hyperthyroid phase); levothyroxine for symptomatic hypothyroidism (in the hypothyroid phase) and for permanent hypothyroidism, Patients may present with thyroid pain and transient thyrotoxicosis, Clinical diagnosis made in the setting of recent previous radiation, Hyperthyroidism generally resolves within one month, Self-limited, but symptoms may be treated with beta blockers and nonsteroidal anti-inflammatory drugs, Very firm goiter or compressive symptoms (dyspnea, stridor, dysphagia), which appear disproportionate to the size of the thyroid; hypocalcemia may occur as a result of fibrotic transformation of the parathyroid glands, Autoimmunity may contribute to the pathogenesis, Most patients are euthyroid, approximately 30% are hypothyroid, Glucocorticoids and mycophenolate (Cellcept); tamoxifen may work by inhibiting fibroblast proliferation, Silent thyroiditis (silent sporadic thyroiditis, painless sporadic thyroiditis, subacute lymphocytic thyroiditis), Hyperthyroidism alone; hyperthyroidism followed by hypothyroidism; or hypothyroidism alone, Euthyroidism is generally achieved by 18 months, but up to 11% of patients become permanently hypothyroid; rarely recurs, Beta blockers can be considered for significant hyperthyroid symptoms (in the hyperthyroid phase); levothyroxine for symptomatic hypothyroidism (in the hypothyroid phase) and permanent hypothyroidism, Subacute thyroiditis (subacute granulomatous thyroiditis, giant cell thyroiditis, de Quervain thyroiditis), Thyroid pain; hyperthyroidism followed by transient hypothyroidism most commonly, Euthyroidism is generally achieved by 18 months, but up to 15% of patients become permanently hypothyroid; rarely recurs, Atrial fibrillation, ventricular arrhythmia, Persistent or recurrent cutaneous T cell lymphoma, psoriasis, graft-versus-host disease, chronic lymphocytic leukemia, Hairy cell leukemia, follicular lymphoma, malignant melanoma, AIDS-related Kaposi sarcoma, chronic hepatitis B and C, Hypothyroidism more often than hyperthyroidism, Gastrointestinal stromal tumors, renal cell carcinoma. Even in euthyroid women, elevated TPO antibodies (anti-TPO) are strongly associated with a higher prevalence of infertility, gestational anemia, miscarriage and preterm delivery. I received my comprehensive thyroid panel test today but dont know how to read it. Thyroid ultrasonography in subacute thyroiditis shows a nonuniform echotexture, hypoechoic areas, and decreased vascularity throughout the gland. The site is secure. This is an autoimmune disease and the most common cause of hypothyroidism. Therefore, this activity can be measured by having an individual swallow a small amount of iodine, which is radioactive. This is an autoimmune disorder where antibodies attack the thyroid, causing inflammation and destruction of the gland. Copyright 2023 American Academy of Family Physicians. Maggie0652 in reply to Clutter 6 years ago. Aspirin (2,600 mg per day in divided doses) or ibuprofen (3,200 mg per day in divided doses) is appropriate. When the heater is off and it becomes cold, the thermostat reads the temperature and turns on the heater. I shouldn't have thyroid left, so why am I now getting high anti thyroid peroxidase antibodies? Graves disease may be differentiated from postpartum thyroiditis by the presence of exophthalmos, thyroid bruit, and positive TSH receptor antibody. The lab's "in range" is not "normal" for everyone. https://www.thyroid.org/thyroid-function-tests/. The timing likely reflects a rebound in immune function after a period of relative immune tolerance during pregnancy. The treatment goal is to restore and maintain adequate T-4 hormone levels and improve . About 95% of people with Hashimoto's have elevated Thyroid Peroxidase Antibodies, while 80% will have elevated Thyroglobulin Antibodies. What Do Herpes Sores Look Like at Different Stages. About 10 percent of patients with chronic autoimmune hypothyroidism have atrophic thyroid glands (rather than goiter), which may represent the final stage of thyroid failure in Hashimoto's thyroiditis. TESTS: - High serum thyroid peroxidase antibody concentrations are present in 90% of these patients. Federal government websites often end in .gov or .mil. Surgery. In the thyroidectomy and thyroid hormone replacement group, the health survey results improved 26 points and the average fatigue score decreased by 9 points. By measuring the amount of radioactivity that is taken up by the thyroid gland (radioactive iodine uptake, RAIU), doctors may determine whether the gland is functioning normally. FREE T3 . sharing sensitive information, make sure youre on a federal Disease Free Survival based on TgAb status. Thyroglobulin antibodies (TgAb) are produced by 10%-25% of thyroid cancer patients and interfere with thyroglobulin measurement, a marker of residual or recurrent cancer after surgery. After RAI antibodies actually can rise dramatically higher than pre treatment. Elevated levels may also indicate a high risk of thyroid cancer recurrence after treatment [ 4. Women with postpartum thyroiditis and subclinical hypothyroidism should be treated with levothyroxine to achieve a thyroid-stimulating hormone level of less than 2.5 mIU per L if they are pregnant or desire fertility. Patients with elevated thyroid peroxidase antibody levels and subclinical hypothyroidism should be monitored annually for the development of overt hypothyroidism. All rights reserved. By using this Site you agree to the following, By using this Site you agree to the following. Objective . Thyroglobulin antibodies were 12 IU/ml (normal levels listed as 0-115) Thyroid peroxidase antibodies were 9 IU/ml (normal levels listed as 0-34) T3 was 4.4 pmol/L (normal listed as 3.1-6.8) Patients who are hyperthyroid will have an elevated T3 level. Bookshelf Copyright 2015 Elsevier Inc. All rights reserved. Therefore, this activity can be measured by having an individual swallow a small amount of iodine, which is radioactive. I was referred to an endochrinologist but can't get in until the end of November. 2 Epub 2018 Oct 30. The purpose of the study was to assess the long-term outcome of DTC patients with raised TgAb. Some reverse T3 is produced normally in the body, but is then rapidly degraded. Epub 2017 Nov 8. The amount of T4 produced by the thyroid gland is controlled by another hormone, which is made in the pituitary gland located at the base of the brain, called thyroid stimulating hormone (abbreviated TSH). This disorder occurs in about 1% of all Americans and affects women much more often than men. Thyroid antibodies are just a piece of the autoimmune thyroid picture. In the case of postpartum, silent, or subacute thyroiditis, the radioactive iodine uptake during the hyperthyroid phase will be low. If it's your antibody levels that are at 300, this would indicate that you have the autoimmune thyroid disease called Hashimoto's Thyroiditis. Epub 2014 May 21. The range resembles what we normally see for TPOab; it means that anything < 30 is negative for antibodies. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action.